The Impact of Omega-3 Fatty Acids on Brain Function and Mental Health

When it comes to nutrition, we often focus on macronutrients like carbohydrates, proteins, and fats. However, fat has received a bad reputation for being “too high in calories”. Many folks shy away from consuming fats, unaware that they are missing out on essential nutrients that are crucial for optimal brain function and mental health. In particular, omega-3 fatty acids have been found to play a vital role in supporting brain health and treating/preventing mental health disorders. In this blog post, we will explore the impact of omega-3 fatty acids on brain function and mental health.

Omega-3 Fatty Acids Explained

Omega-3 fatty acids are a type of essential fatty acid that our bodies cannot produce on their own. There are two main types of omega-3 fatty acids: docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA is primarily found in the brain, retina, and sperm cells, while EPA is more abundant in the body tissues and plays a role in reducing inflammation. Both DHA and EPA are critical for brain health and function.

While our bodies can convert a small amount of omega-3 fatty acids from plant-based sources like flaxseed, walnuts and chia seeds, the most effective way to obtain sufficient amounts of DHA and EPA is through animal-based sources. Fatty fish such as salmon, mackerel, and sardines are excellent sources of omega-3 fatty acids. Other sources include algae-based supplements and certain fortified foods. Incorporating these foods into our diet can help ensure we are getting an adequate amount of omega-3 fatty acids.

In addition to DHA and EPA, there are also omega-3 fatty acids called alpha-linolenic acid (ALA), which can be found in plant-based sources like walnuts, flaxseeds, and chia seeds. However, it's important to note that ALA is not as easily converted to DHA and EPA in the body as the animal-based sources.

Deficiency and Mental Health Disorders

Research has shown that a dietary deficiency in omega-3 fatty acids is associated with an increased risk of several mental health disorders. Depression, anxiety, bipolar disorder, dementia and attention deficit hyperactivity disorder (ADHD) are some of the conditions that have been linked to low levels of omega-3 fatty acids in the body.

One study published in the Journal of Clinical Psychiatry found that individuals with major depressive disorder had significantly lower levels of omega-3 fatty acids compared to those without depression.  

Moreover, omega-3 fatty acids have been found to play a crucial role in the development and maintenance of brain function throughout life. They support the production of brain-derived neurotrophic factor (BDNF), a protein that promotes the growth and survival of neurons in the brain. Low levels of BDNF have been associated with various mental health disorders, including depression and schizophrenia.

However, don’t just run out and buy yourself an omega-3 supplement without talking to your healthcare team first.  A meta-analysis from 2019 published in the British Journal of Psychiatry did not find enough evidence to recommend omega-3 supplementation for decreasing risk of depression.  It’s important that any supplementation is intentional and a part of your individualized care plan to be therapeutic.

Omega-3s and Brain Function

Omega-3 fatty acids play a vital role in optimizing brain function. They improve signal transmission between brain cells, which is crucial for cognitive processes such as learning, memory, focus, and attention. Additionally, omega-3s are essential for the structure and mass of the brain. They help maintain the integrity of cell membranes in brain cells, allowing for efficient communication and functioning.

Research has shown that individuals with higher levels of omega-3 fatty acids in their blood have better cognitive function, including improved memory and attention. A study published in the American Journal of Clinical Nutrition found that higher fish consumption, which is a major source of omega-3 fatty acids, was associated with a reduced risk of cognitive decline and dementia in older adults.

Incorporating omega-3 fatty acids into our diet is not only beneficial for brain health but also for overall mental well-being. These essential fatty acids are a critical component of intentional nutrition for mental health, and we should not overlook their importance by solely focusing on weight as an outcome.

Conclusion

Have I convinced you yet to stop looking at the calories? Omega-3 fatty acids, particularly DHA and EPA, are essential for optimal brain function and mental health. Incorporating sources of omega-3 fatty acids into our diet, can help ensure we are getting the necessary nutrients to support cognitive processes, improve memory, and support our mental health. By prioritizing intentional nutrition instead of weight loss, we can take a proactive approach in caring for our brain and overall well-being.

Citations:

Gómez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci. 2008 Jul;9(7):568-78. doi: 10.1038/nrn2421. PMID: 18568016; PMCID: PMC2805706.


Wani AL, Bhat SA, Ara A. Omega-3 fatty acids and the treatment of depression: a review of scientific evidence. Integr Med Res. 2015 Sep;4(3):132-141. doi: 10.1016/j.imr.2015.07.003. Epub 2015 Jul 15. PMID: 28664119; PMCID: PMC5481805.


Deane, K., Jimoh, O., Biswas, P., O'Brien, A., Hanson, S., Abdelhamid, A., . . . Hooper, L. (2021). Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: Systematic review and meta-analysis of randomised trials. The British Journal of Psychiatry, 218(3), 135-142. doi:10.1192/bjp.2019.234


Bao-Zhen Wei, Lin Li, Cheng-Wen Dong, Chen-Chen Tan. (2023). The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers. The American Journal of Clinical Nutrition. DOI:https://doi.org/10.1016/j.ajcnut.2023.04.001

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